Regular Turmeric & Curcumin Supplement Benefits in Over 15 (Small) Human Studies

Turmeric is a spice derived from the roots of the entire plant, and it’s deep orange colour under the peel is due to pigments such as curcumin. Commonly used in traditional dishes for flavour and curry in Southeast Asia, this Indian spice is also used in dyes, cosmetics and even medicines (1). Besides being enjoyed in flavourful or spicy dishes, traditional claims of turmeric’s healing has inspired a wealth of experimental research into the health impact of turmeric intake. Beyond preclinical tests of this spice with isolated cells or in animal trials, an informed look at the humans studies of regular turmeric intake shows numerous health benefits. Better yet, exotic turmeric preparations were not needed for many of the health benefits detected in several studies; the golden spice was often good enough!

Most readers will be familiar with antibiotics and the concept of completing a prescribed course for the desired effect: clearing an infection. Taking too much or too little produces unique health complications in each instance. Although turmeric is not a drug, medicine or treatment, the clinical research into the effects turmeric supplements have on patients of various diseases/conditions can be very informative for those looking to take a proactive approach to their own health, a decision that should be based on consultation with a qualified and informed doctor.

Turmeric is a spice mainly grown at large scales in tropical regions of Asia’s, as well as parts of Africa, and is fairly synonymous with curry dishes of India. Daily intake of turmeric in India has been determined to range from 0.24 grams (16) per day up to 4 grams per day (per person) (17). The yellow colour of turmeric, and most of it’s bioactive properties are attributed to the pigment curcumin, which accounts for 2–5% of turmeric by weight (2), has a vast number of different enzymes it interacts with and alters the activity of (1), and yet has a low absorption rate in the body (regardless of health status).

Naturally, much of the research around turmeric focuses on curcumin’s activity. As a powerful antioxidant curcumin protects cell membranes (18), is an inhibitor of inflammatory signals (19), and anti-cancer agent by increasing cancer cell susceptibility to chemo- (20) and radio-therapy (21), as well as directly stimulating an increase in cell death of many different cancer cell types (22, 23, 24). There is also significant interest in increasing curcumin absorption rates using black pepper-extracted piperine (which boosts curcumin absorption by as much as 2 to 20 times (25)), as well as using refined oils to encapsulate curcumin in different ways (e.g. liposomes, micelles, etc) (2).

A large amount of the research interest in turmeric has been focused on it’s oil-soluble pigment curcumin, and increasing curcumin’s bio-availability and consequently effectiveness (from the same amount of curcumin supplement intake) (1, 2). Even a water-soluble, concentrated extract from boiled turmeric improved scores on stress and positive mood surveys, lowered blood sugar sticking to haemoglobin, and lowered multiple bloodstream markers for inflammation (C-reactive protein, tumor necrosis factor-α, interleukin-6, and soluble vascular cell adhesion molecule-1) (26). This was achieved in 50–69 year olds who were overweight or prehypertension/mild hypertension (but otherwise healthy) after 12 weeks of supplementation, and indicates that this low-curcumin turmeric extract still has health-supporting properties.

Turmeric Starts Working in the Gut

However taking whole-turmeric (in various forms) retains multiple positive effects on human health, the golden spice appears to get to work as soon as it enters the stomach! Peptic ulcer patients taking turmeric in the form of two 300 mg capsules, five times daily before meals resulted in 48% clearance of ulcers after four weeks (4). Continued turmeric capsule intake further increased the absence of ulcers to 78% of test patients after 12 weeks, demonstrating the importance of maintaining regular consumption of healthy foods as discussed prior with beetroot and cherry supplements.

A positive increase in bowel motility and activation of hydrogen-producing gut bacteria in the colon were observed in a separate study of healthy subjects after a 500 mg dose of turmeric delivered via curry (27). In another trial irritable bowel syndrome sufferers were given either one or two tablets of 72 mg turmeric extract daily, and roughly two-thirds of all subjects experienced improvements in symptoms after 8 weeks, regardless of extract dose (5).

The golden spice and it’s extracts (photo credit: NirmalSarkar)

Kidney Function and Turmeric

Whether kidney disease is a result of autoimmune disease (lupus nephritis (6)) or type 2 diabetes (7), protein leakage from the kidneys into urine (i.e. proteinuria) was significantly reduced amongst turmeric supplement takers. Amongst lupus patients, 500 mg of turmeric daily for 3 months also lowered leakage of red blood cells into urine and blood pressure (i.e. systolic) (6). Diabetes patients taking three 500 mg doses of turmeric daily for 2 months experienced significant reductions in blood inflammatory signals (IL-8 and TGF-beta), alongside proteinuria (7).

A single 6 gram dose of turmeric taken simultaneously with a 75 gram glucose test (to determine blood sugar control) increased circulating insulin levels within 15 minutes to 2 hours after ingestion (28). However circulating glucose levels were not statistically different whether test subjects took turmeric or the placebo. A separate study found that 400 mg of turmeric extract, in combination with 400 mg garlic extract (taken 3 times daily) lowered blood glucose levels 2 hours post-meal, a crucial timepoint at which blood sugar needs to be managed by transportation into the body’s organs for usage (13). Theoretically, the herb moringa could also complement the post-meal raise in insulin levels and contribute to efficient reduction of blood sugar levels.

Turmeric Extracts, Pain and Cancer

Several studies have associated turmeric and curcumin with pain relief, a property which is based on anti-inflammatory activity (29). Recent work has identified a water-soluble molecule from turmeric, calebin A, which has significant antioxidant properties and lowered levels of inflammatory cell signals (via nuclear factor kappa B and scleraxis) in tendon cells (i.e. tenocytes) (30). A comparison of 15 randomised controlled trials found that either turmeric extract or curcumin users experienced significant pain alleviation from osteoarthritis, and adverse event reported occurred at comparable rates in the curcumin and placebo (31). The comparison of these trials concluded that turmeric extract or curcumin intake was most effective after a minimum intake period of 12 weeks.

Application of an ethanol extract of turmeric was able to produce significant symptomatic relief in patients with cancerous external lesions after months, although 1 out of 62 subjects experienced an adverse reaction (32). A daily turmeric intake of 1.5 grams for 30 days lowered the levels of mutation-promoting chemicals in the urine of chronic smokers, whereas non-smokers on the same turmeric regimen saw no change in mutagen excretion (33). Release of mutagens in the urine indicates an inability to detoxify/neutralise those chemicals, which appears to have been increased amongst smokers taking turmeric supplements.

There appears to be an inhibition of mutations at a fundamental level, as turmeric extract lowered the formation of damaged DNA/chromosome structures (i.e. micronuclei) in circulating white blood cells of healthy study participants (34). This correlated to the impact of a daily intake of three 375 mg curcumin doses amongst five patients with inflammatory tumour-like structures (i.e. idiopathic inflammatory orbital pseudotumors) (35). Four of the patients experienced complete recovery after 6 to 22 months of intake with no adverse events reported. High-risk patients with various cancer types were given 0.5 – 8 grams daily of curcumin, and after 3 months 1 patient in each of the 5 cancer type-test groups had observable improvements in their tissue samples (36). Two out of 25 pancreatic cancer patients who took 8 grams of curcumin daily and no chemo- or radiotherapy experienced tumour regression after 8 weeks, and fortunately no toxicity was observed (37).

Safety

Toxicity of turmeric or curcumin is rarely observed in studies, however a study in genetically-modified mice found an increase in average tumour numbers after ingestion of curcumin, and application of curcumin to colon cancer cells resulted in malfunction of the tumour-suppression enzyme p53 (25). To our knowledge these adverse events have not been replicated in other studies with animals, or in trials with people.

Regular Turmeric Intake Benefits?

The regular intake of turmeric in India ranges from 0.24 – 4 grams daily is frequently accompanied with ghee or black pepper (amongst other ingredients), both of which are likely to increase absorption/bio-availability of curcumin (25). The high consumption of turmeric in India has been correlated to the relatively low incidence of many types of cancer in India, although many additional factors are likely to contribute to lower cancer rates, such as dietary choices and regularly eating many other spices with preliminary evidence of anti-inflammatory properties (25).

The frequent curry consumption (and implied turmeric intake) in India has also been correlated with improved cognitive performance amongst the elderly (38). Curcumin supplementation has been explored with respect to alzheimers disease progression, and increasing bio-availability (as described earlier) could increase beneficial outcomes observed in trials (15). Curcumin also produces an anti-inflammatory effect via certain immune system-linked receptors (i.e. AhR (39) and PPAR-gamma (40)) that can otherwise be “hijacked” by synthetic hormone disrupting chemicals to weaken the immune system in many ways.

A daily intake of reasonable amounts of turmeric has been shown in healthy and unwell people to show a broad range of benefits in small trials. In more severe disease cases, concentrated turmeric extracts also demonstrated some efficacy. Many of the studies referenced in this article correctly recognised that the improved outcomes trial participants taking turmeric supplements experienced need to be reproduced amongst a larger set of participants to confirm those observations definitively.

However, the reproducibility of patients experiencing symptomatic improvements (from many different illnesses) does serve as a reasonable basis to assert that turmeric and it’s extracts are associated with multiple improved health outcomes under experimental settings. Irrespective of health condition being investigated, sustaining taking turmeric regularly over multiple weeks ultimately coincided with better results. There is an instinctive desire to take turmeric (and even other health foods) in its most natural form as a whole spice for many, but this may become numbingly repetitive over weeks! The prospect of getting bored with endless curries or turmeric smoothies emphasises the relevance of quality food supplements, which provide a pragmatic and accurate alternative for completing a multi-week course of turmeric.

Odeshe’s Turmeric & Curcumin Extract, with black pepper, ginger and other vitamins & minerals

Disclaimer: If you have medical concerns, please consult your doctor before implementing the opinions in this article.

by

The Odeshe Team.

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